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When sucked into a tumor’s skin pores, the nanoparticles’ outer membrane disintegrates, rapidly deploying the anti-angiogenic drug-causing arteries feeding the tumor to collapse, and trapping the loaded nanoparticle. Inside the tumor, the nanoparticles release a chemotherapeutic agent gradually, such as camptothecin and docetaxel, while leaving healthy cells unscathed. This avoids a significant problem of chemotherapy: its toxicity to the healthy cells surrounding cancerous ones.
This system was defined in a paper published in 2005 in Nature. The following year, in 2006, Sasisekharan co-founded Cerulean to commercialize the technology; today, it remains mostly of the companies using nanotechnology to take care of cancer. But because nanotechnology continues to be relatively new, Cerulean is working on ways to enhance the platform.
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85 million and partnered with cancer centers and private hospitals around the nation to further refine its technology; its first medication candidate, CRLX101, has moved into clinical tests. Sasisekharan says. “In a couple of years we may see an authorization of ‘nanodrugs’ for oncology applications.” Cerulean was one of a few Boston-area biotech companies to look public recently. While growing Momenta and Cerulean, Sasisekharan slowly assembled the items for his most recent business, Visterra, which focuses on a separate global health issue: influenza and other infectious diseases. In 2003, during a trip along with his wife to Thailand (where Sasisekharan spends most summers teaching), he found himself in the center of the country’s H5N1 epidemic.
The flu ravaged the chicken industry in Thailand. Nudged by the princess of Thailand to address a global ailment, Sasisekharan worked with an MIT team to determine how and when parrot flu may make the leap from birds to humans. Sasisekharan and his MIT team found ultimately, five years later, that H5N1’s hemagglutinin, a proteins on the disease surface, must bind to your umbrella-shaped receptors in order to infect humans.
Published in 2008 in Nature Biotechnology, this breakthrough could help scientists monitor the pathogen’ progression and develop vaccines against a fatal flu pandemic. Sasisekharan and his team applied this process more recently to the growing N7N9 influenza pathogen, with results published in 2013 in Cell. Visterra grew from the book technology Sasisekharan and his team invented for this research-which mixed computation and bioengineering.
Using algorithms, the technology builds a 3-D style of key viral protein and identifies optimum hierotopes-sites where antibodies bind-on the viral hemagglutinin. These sites are found across all 15 influenza A subtypes, but don’t mutate-meaning they can’t develop level of resistance to vaccines. Visterra scientists build and tweak antibodies, using bioengineering tools, to specifically focus on these hierotopes.
Visterra’s first commercial antibody, called VIS410, is in its first stage of clinical studies now; it gets the potential to vaccinate against all influenza A subtypes. 40 million in business capital-to help develop its infectious disease product pipeline. Year Next, that pipeline can include another restorative applicant, for an equally deadly virus: the mosquito-borne dengue. In a 2009 trip to Singapore as part of the Singapore-MIT Alliance for Technology and Research, Sasisekharan saw that the country was “ground zero” for dengue.